Postoperative pulmonary complications
Conditions
Interventions
Experimental group:Subjects will receive low tidal volume ventilation of 3 ml/kg ideal body weight (IBW) during CPB, respiratory rate 5 times/min, inhaled oxygen concentration: 40%-60% to maintain SPO
Control group:Subjects were also ventilate at low tidal volume of 3 ml/kg ideal body weight (IBW) with a respiratory rate of 5 times/min and a PEEP setting of 3-5 cmH2O during CPB, but without lung re
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Patients who plan to undergo cardiac surgery under cardiopulmonary bypass; 2) Age >=18 years old; 3) Subjects voluntarily sign informed consent for this study.
Exclusion criteria
Exclusion criteria: 1) Emergency surgery; 2) Prior open-heart surgery; 3) Preoperative diagnosis of pulmonary infection; 4) Mechanical ventilation within 2 months before surgery; 5) Acute heart failure within 2 months before surgery; 6) Heart transplantation and pulmonary thrombointimectomy were proposed; 7) Aortic arch and other cryogenic circulatory stop operations were proposed; 8) American Society of Anesthesiologists (ASA) Grade IV to V; 9) Have participated in other similar trials within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of pulmonary complications within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of oxygenation index change 24 hours after surgery;IL-6 changes 24 hours after operation;CRP changes 24 hours after operation;PCT changes 24 hours after operation;Length of postoperative ICU stay;Total hospital stay;Postoperative mechanical ventilation time; | — |
Countries
China
Contacts
Public ContactXiao Wang
West China Hospital, Sichuan University
Outcome results
None listed