Sepsis-associated encephalopathy,SAE
Conditions
Interventions
Gold Standard:The uncontrolled response of the body to infection can lead to life - threatening organ dysfunction, among which SOFA) >=2
All patients with SAE are those with sepsis accompanied by different degrees of consciousness disorders, and their Glasgow Coma Scale are less than 15.
Index test:GCS <15
Sponsors
The First People's Hospital of Lianyungang
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The selected patients were all newly admitted or untreated patients with sepsis aged 18-80 years; 2. All selected patients with sepsis met the diagnostic criteria for sepsis 3.0; 3. The patients in the SAE group were all patients with sepsis with varying degrees of consciousness impairment, and the GCS score was < 15 points and did not meet one of the exclusion criteria. 4. Those with complete clinical data, themselves or their family members sign the informed consent form. 4.Those with complete clinical data, and the patients themselves or their families sign the informed consent forms;
Exclusion criteria
Exclusion criteria: 1. Patients with intracranial hemorrhage, intracranial organic lesions, central nervous system infection and metabolic encephalopathy; 2. Patients with new cerebral infarction, sequelae of previous cerebral infarction, senile dementia and other long-term mental disorders; 3. Combined with other diseases that can cause consciousness disorders, such as hepatic encephalopathy, pulmonary encephalopathy, trauma and other factors; 4. Long-term mental illness, such as depression, anxiety, mania, etc., or long-term oral psychotropic drugs; 5. Patients who use long-acting or short-acting sedative drugs or receive special treatment before admission; 6. Severe cardiovascular and cerebrovascular emergencies, liver and kidney insufficiency and other diseases; 7. Patients who died within 24 hours after admission and those who refused to be examined.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GBP5S ;NSE;S100ß; | — |
Countries
China
Contacts
Public ContactXiaomin Li
The First People's Hospital of Lianyungang
Outcome results
None listed