Hemorrhoids
Conditions
Interventions
Control group:Administer a local infiltration injection of 10 ml of 0.75% ropivacaine diluted to a total volume of 30 ml at the incision site
Study Group:Administer a 30 ml diluted solution of bupivacaine liposome for local infiltration injection at the incision site
Sponsors
Tianjin Medical University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Male or female, age >=18 years; 2) Patients with clinical diagnosis of III.~IV. internal hemorrhoids, external hemorrhoids or mixed hemorrhoids combined with prolapse; 3) ASA Grades I-III; 4) 18.5kg/m2<=body mass index (BMI)<=28kg/m^2; 5) Have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Patients with psychiatric diseases and cognitive dysfunction; 2) Patients with sensory impairments such as hyperalgesia, or other somatic pain that affects postoperative pain assessment; 3) History of myocardial infarction or unstable angina pectoris within half a year, or history of severe arrhythmia (if there is atrioventricular block of grade II or above); 4) patients with diabetic peripheral neuropathy; 5) abnormal liver function: aspartate aminotransferase (AST) or/and alanine aminotransferase (ALT) and/or total bilirubin (TBIL) >=1.5×ULN; 6) Those who are known to be allergic to bupivacaine or other amide local anesthetics; 7) Pregnant and lactating female patients, as well as patients who have a birth plan within half a year and are unwilling or unable to take effective contraceptive measures; 8) Patients with any other factors that, in the opinion of the investigator, are not suitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Area Under the Curve of the Pain Intensity Score on the Numerical Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting and movement state NRS scores ; | — |
Countries
China
Contacts
Public ContactGang Liu
Tianjin Medical University General Hospital
Outcome results
None listed