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The impact of colostrum oral care on the postnatal growth of premature infants based on the early gut microbiota-host interaction model

The impact of colostrum oral care on the postnatal growth of premature infants based on the early gut microbiota-host interaction model

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094495
Enrollment
Unknown
Registered
2024-12-24
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extra Uterine Growth Restriction

Interventions

Intervention group:During the first 48 to 72 hours, the treatment group used two sterile 1ml syringes to extract 0.1ml of colostrum and let it rest at room temperature for 5 minutes to restore the app
Control group:For the control group, normal saline was used instead of colostrum, and the procedure was the same as that of the treatment group.

Sponsors

Jiangsu Province (Suqian)Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 34 Weeks

Inclusion criteria

Inclusion criteria: Gestational age less than 34 weeks; They were admitted to the neonatal intensive care unit within 24 hours of birth; Able to start the protocol within 72 hours of birth and can continue to provide sufficient colostrum until the end of the protocol.

Exclusion criteria

Exclusion criteria: Death within 48 hours; Severe birth asphyxia (defined as umbilical artery/first hour arterial blood gas pH<7.0); Born with severe gastrointestinal malformations (such as intestinal atresia, esophagotracheal fistula, intestinal rotation abnormalities, and Hirschsprung's disease); Prenatal diagnosis of congenital chromosomal abnormality or suspected congenital genetic metabolic disease; The mother abused drugs or had contraindications to breastfeeding (HIV, etc.).

Design outcomes

Primary

MeasureTime frame
Intergroup differences in the incidence of extrauterine dysplasia at discharge;

Secondary

MeasureTime frame
Extra Uterine Growth Restriction;Between-group differences in time to regain birth weight;

Countries

China

Contacts

Public ContactJia Zhang

Jiangsu Province (Suqian)Hospital

15851085557@sina.cn+86 158 5108 5557

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026