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The effect of different titration methods of PEEP on lung function in patients undergoing laparoscopic Trendelenburg surgery: a clinical randomized single blind controlled trial

The effect of different titration methods of PEEP on lung function in patients undergoing laparoscopic Trendelenburg surgery

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094491
Enrollment
Unknown
Registered
2024-12-24
Start date
2024-12-30
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative atelectasis in laparoscopic Trendelenburg position

Interventions

DP group:Drive pressure guide PEEP
CP group:Lung compliance guide PEEP
P group:Fixed PEEP= 6cmH2O

Sponsors

Chengdu Wenjiang District People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All patients who had elective laparoscopic surgery, Trendelenburg position, age >18 years old, gender not limited, ASA grade I to III, BMI 18 to 28 kg/m2, normal mental state, were successfully removed after the operation, and the Pneumoperitoneum time was >=1.5 hours.

Exclusion criteria

Exclusion criteria: Exclusion criteria: 1. Previous history of lung surgery, pneumothorax, thoracic malformation, pulmonary bullae, chronic obstructive pulmonary disease (COPD), pulmonary infection or pleural effusion, and history of mechanical ventilation (including continuous mechanical ventilation) in the past 2 weeks; 2. Chronic myocardial ischemia or severe cardiovascular disease; 3. Severe liver and kidney dysfunction (liver dysfunction, Child Pugh C or D grade, Creatinine>200 µ mol/L); 4. Change to open surgery during the operation, and enter the ICU after the operation; 5. The duration of pneumoperitoneum is less than 1.5 hours;

Design outcomes

Primary

MeasureTime frame
PaO2;Pulmonary ultrasound score;

Secondary

MeasureTime frame
Incidence of pulmonary complications;

Countries

China

Contacts

Public ContactXu Chiliang

Chengdu Wenjiang District People's Hospital

474311445@qq.com+86 138 8010 7981

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026