Gram-negative bacterial infection
Conditions
Interventions
Gram-negative drug-resistant bacterial infection patients:Blood samples were collected at different time points for drug concentration monitoring.
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old. 2.Diagnosed with severe infections (such as sepsis, pneumonia, intra-abdominal infections) caused by Gram-negative drug-resistant bacteria. 3.Receiving treatment with colistin sulfate (including loading and maintenance doses), with an expected treatment duration of >= 48 hours. 4.ICU inpatients with stable conditions, capable of undergoing blood sample collection. 5.Consent to participate in the study and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Allergic to any component of colistin sulfate for injection. 2.Pregnant women, breastfeeding women, or patients planning to become pregnant in the near future. 3.Inability to collect sufficient blood samples due to medical conditions or technical reasons. 4.Patients deemed unsuitable for participation in the study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration;Serum Biochemistry;Coagulation Function;Arterial Blood Gas Analysis;Electrocardiogram;Chest Computed Tomography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs;Complete Blood Count; | — |
Countries
China
Contacts
Public ContactYun Cai
Chinese PLA General Hospital
Outcome results
None listed