Postoperative Delirium
Conditions
Interventions
Dexmedetomidine nasal drops group:Dexmedetomidine hydrochloride nasal drops from 20:00 to 21:30 the day before surgery.
Normal saline control group:The day before surgery 20:00 to 21:30 equal volume normal saline nasal drip.
Sponsors
The First Affiliated Hospital of Hebei North University
Eligibility
Sex/Gender
All
Age
60 Years to 79 Years
Inclusion criteria
Inclusion criteria: (1)Age 60 ~ 79 years old;(2)ASA Grade II/III;(3)Elderly patients undergoing abdominal tumor surgery under general anesthesia;(4)Preoperative Amsterdam Preoperative Anxiety and Information Needs Scale score greater than 11 points;(5)Patients and their families clearly understand, voluntarily participate in the study, and sign informed.
Exclusion criteria
Exclusion criteria: (1)Patients who can't sign informed consent;(2)Patients who do not understand Chinese;(3)Severe respiratory or cardiovascular disease;(4)Severe liver disease (Childs-Pugh score Class C);(5)Severe audio-visual impairments hinder communication;(6)Study drugs for allergic reactions, allergies, or contraindications;(7)Patients with dementia or preoperative MMSE score of illiterate patients 15;(11)Severe snoring;(12)obesity(BMI>23.9kg/m^2);(13)Severe sinus bradycardia (HR<=45 beats/min) and atrioventricular block of degree ? or above;(14)No post-operative follow-up is possible;(15)There are other circumstances in which the investigator considers it inappropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 7 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative recovery quality;Postoperation pain;Incidence of postoperative agitation;Incidence of postoperative nausea and vomiting;Anxiety level on the day before operation and the morning of operation (before operation);The number of intraoperative episodes of hypotension/hypertension (defined as MAP exceeding 20% of the baseline value) for 1 consecutive minute were recorded.;The number and dosage of vasoactive drugs used during the operation;Duration of stay in PACU;Intraoperative atropine dose; | — |
Countries
China
Contacts
Public ContactYao Jie
The First Affiliated Hospital of Hebei North University
Outcome results
None listed