Chronic Lymphocytic Thyroiditis
Conditions
Interventions
Placebo group:Lifestyle intervention
Vitamin D2 low dose group :Vitamin D2, 1000 units orally daily
Vitamin D2 high dose group:Vitamin D2, 4000 units orally daily
Sponsors
Beijing Shijingshan Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with an age range of 18 to 70 years old, confirmed to be chronic lymphocytic thyroiditis according to clinical and laboratory examinations, that is, subclinical hypothyroidism with anti-thyroid peroxidase antibody TPOAb, anti-thyroglobulin antibody TgAb, anti-thyroid microsomal antibody TMAb, and thyroid-stimulating hormone receptor antibody TRAb, any one of which is positive, and there is no abnormality in thyroid function or thyroid-stimulating hormone (TSH) <10mU/L; 2. Vitamin D deficiency (25-hydroxyvitamin D (25OHD)<20ng/mL); 3. No other serious medical or surgical diseases; 4. Not receiving recent thyroid hormone or other medications that affect thyroid function; 5. Willing to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.1 patients with type 1 diabetes; Acute complications (e.g., DKA, etc.); 2. Accompanied by other autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, etc.; 3. Unexplained hypercalcemia; 4. Are using proton pump inhibitors, glucocorticoids, estrogen, antiepileptic drugs and other drugs that affect vitamin D metabolism; 5. Have taken calcium and vitamin D drugs in the past 6 months; 6. Patients with abnormal liver and kidney function; 7. Acute and chronic infectious diseases; 8. Occurrence of acute cardiac and cerebrovascular events (including stroke, acute coronary syndrome, etc.); 9. Patients with anemia, malignant tumors, parathyroid diseases, anorexia nervosa and gastrointestinal short-circuit surgery; Those who have taken weight loss drugs or drugs that affect BMI within 10.6 months, such as laxatives; 11. Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thyroid antibodies;Five items of armor; | — |
Secondary
| Measure | Time frame |
|---|---|
| 25-hydroxyvitamin D; | — |
Countries
China
Contacts
Public ContactYan Xu
Beijing Shijingshan Hospital
Outcome results
None listed