Benign gallbladder lesions
Conditions
Interventions
Gallstone group (GS):None
Gallbladder Polyps group (GP):None
Gallstones combined with gallbladder polyps group (SP):None
Standardized treatment group for grade 1/2 patients:Standardized Ursodeoxycholic Acid Prophylactic Treatment for Half a Year
Standardized treatment group for grade 3/4 patients:Standardized Ursodeoxycholic Acid Prophylactic Treatment for One Year
Non standardized treatment group for grade 1/2 patients:Unsupervised Ursodeoxycholic Acid Prophylactic Treatment for Half a Year
Non standardized treatment group for grade 3/4 patients:Standardized Ursodeoxycholic Acid Prophylactic Treatment for One Year
Sponsors
The 909th hospital (Southeast Hospital of Xiamen University)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy Volunteers: 1) Volunteers with physical examination and no symptoms of disease; 2) The results of abdominal ultrasound showed that there was no abnormality in the hepatobiliary, pancreatic and spleen; 3) No other serious diseases; 4) Serum and fecal samples were collected at the time of enrollment and frozen at -80°C. Inpatients to be treated with NOTES cholecysticide: 1) A full set of blood biochemistry tests within one week before surgery; 2) Abdominal color ultrasound examination within three months before surgery, indicating gallstones or gallbladder polyps; 3) After NOTES chole-sparing therapy, it was determined that the lesion was gallstone or gallbladder polyp; 4) Serum and fecal samples were collected at the time of enrollment and frozen at -80°C. Follow-up patients who have undergone NOTES gallbladder-sparing therapy: 1) Abdominal ultrasound examination within three months before surgery, indicating gallstones or gallbladder polyps, and the postoperative lesions were confirmed to be gallstones or gallbladder polyps; 2) Agree and cooperate with the corresponding half a year or one year of ursodeoxycholic acid treatment according to the risk level of recurrence; 3) Agree and cooperate with the routine blood biochemical test before and after treatment, abdominal color ultrasound examination, and give blood samples and stool samples.
Exclusion criteria
Exclusion criteria: Healthy Controls: 1) Have obvious symptoms of disease; 2) Lack of abdominal color ultrasound results or suggestive of hepatobiliary, pancreatic and splenic abnormalities; 3) Have serious diseases, such as long-term hypertension, diabetes, liver cirrhosis, cancer, etc.; 4) No serum and stool samples were collected at the time of enrollment. Inpatients to be treated with NOTES cholecysticide: 1) No complete set of blood biochemical test reports within one week before surgery; 2) No abdominal ultrasound examination within three months before surgery; 3) Postoperative lesions are not gallstones or non-gallbladder polyps; 4) No serum and stool samples were collected at the time of enrollment. Follow-up patients who have undergone NOTES gallbladder-sparing therapy: 1) After surgery, it was clear that the lesions were non-gallstones and non-gallbladder polyps; 2) Unwilling or uncooperative to give ursodeoxycholic acid treatment for half a year or one year according to the risk level of gallstone or polyp recurrence; 3) Do not agree or cooperate with the pre-treatment and post-treatment routine blood biochemical tests, abdominal color ultrasound examination, and give blood specimens and stool specimens.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol (TC);Triglycerides (TG);Apolipoprotein A1 (APOA1);Apolipoprotein B (APOB);High density lipoprotein cholesterol (HDL-C);Low density lipoprotein cholesterol (LDL-C);Cholic acid (CA);Lithocholic acid (LCA);Deoxycholic acid (DCA);Ursodeoxycholic acid (UDCA);Chenodeoxycholic acid (CDCA);Taurocholic acid (TCA);Taurolithocholic acid (TLCA);Taurodeoxycholic acid (TDCA);Tauroursodeoxycholic acid (TUDCA);Taurochenodeoxycholic acid (TCDCA);Glycocholic acid (GCA);Glycolithocholic acid (GLCA);Glycodeoxycholic acid (GDCA);Glycochenodeoxycholic acid (GCDCA);Glycoursodeoxycholic acid (GUDCA);Abdominal ultrasound; | — |
Countries
China
Contacts
Public ContactLixin Deng
The 909th hospital (Southeast Hospital of Xiamen University)
Outcome results
None listed