Pulmonary malignant tumor
Conditions
Interventions
Liposomebupivacaine Group(LB Group):Under ultrasound guidance, unilateral paravertebral block was performed by injecting 15ml of bupivacaine liposomes (a 10ml: 133mg bupivacaine liposome diluted with
Bupivacaine Hydrochloride Group(BH Group):Under ultrasound guidance, unilateral paraspinal block was performed by injecting 15ml of 0.25% bupivacaine (a 5ml mixture of 0.75% bupivacaine and 25ml steri
Control Group(C Group):None
Sponsors
The Second Hospital & Clinical Medical School, Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.No gender restrictions, age>= 18 years old; 2.ASA= 27 points; 4. This study has been approved by the Medical Ethics Committee of our hospital, and patients have signed informed consent forms; 5. Patients diagnosed with non-small cell carcinoma of type I, II, or IIIa who are planning to undergo thoracoscopic assisted (single port) radical resection for lung cancer.
Exclusion criteria
Exclusion criteria: 1.Allergy to anesthetic drugs, significant functional impairment of vital organs such as respiration, circulation, liver and kidney before surgery; 2.Preoperative examination results indicate distant metastasis; 3. Preoperative radiotherapy, chemotherapy, and hormone therapy; 4.Long term use of sedatives and analgesics, and perioperative blood transfusion therapy; 5. Participated in other studies within the past three months and suffered from other malignant tumors;6.Those who are not suitable for thoracic paravertebral nerve block, such as those with back infections, spinal deformities, etc; 7.Those who have difficulty completing follow-up or have various factors that affect compliance;8.Pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cellular immune related indicators;Blood glucose;Related complications and adverse reactions: nausea, vomiting, fever, constipation, dizziness, headache, insomnia, itching, pneumothorax, atelectasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale(VAS);Intraoperative hemodynamic indicators;Incidence of vascular adverse events in the surgical center;Intraoperative use of vasoactive drugs;Intraoperative sedative dosage;Intraoperative remifentanil dosage;15 Quality of Recovery Scale (QoR-15) Score;First press time and cumulative press frequency of postoperative analgesia pump;Consumption of sufentanil 24 hours and 24-48 hours after surgery;The number of people in need of remedial analgesia, the frequency of remedial analgesia, and the type and dosage of remedial analgesia drugs; | — |
Countries
China
Contacts
Public ContactWang Yingbin
The Second Hospital & Clinical Medical School, Lanzhou University
Outcome results
None listed