anti-interferon-? autoantibody immune deficiency syndrome
Conditions
Interventions
Test group:Immunosorbent therapy
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. >=18 years of age; 2. HIV antibody negative; 3. No glucocorticoids, immunosuppressants, immunocytotoxic biologics, and antitumor drugs were used in the whole body within 1 year; 4. No other active autoimmune disease or uncured malignancy; 5. Primary immunodeficiency disease has not been diagnosed; 6. Any one or more of the following infectious diseases were diagnosed at the time of admission: disseminated Marneffei basiomycosis, disseminated tuberculosis, disseminated nontuberculous mycobacterium infection, disseminated cryptococcosis, disseminated nocardia infection, disseminated histoplasmosis, disseminated nontyphoid salmonella infection, etc.; 7. AIGAs positive in peripheral blood.
Exclusion criteria
Exclusion criteria: 1. Severe active bleeding or disseminated intravascular coagulation at the time of enrollment; 2. Hemodynamic instability such as shock and malignant arrhythmia; 3. Severe allergies to plasma, heparin, protamine, etc.; 4. Acute stage of myocardial infarction and cerebral infarction; 5. Other cases that do not agree or do not cooperate with immunosorbent therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The period of remission of a patient's disseminated infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| AIGAs;clinical index;Image index;Thrombotic event;Physicochemical index; | — |
Countries
China
Contacts
Public ContactJing Liu
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed