Similarities and Differences in Subthalamic Nucleus Neuronal Activity during Anesthetic Emergence and Sleep-Wake Transitions in Parkinson's Disease Patients

Status

Recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400094432

Enrollment

Unknown

Registered

2024-12-23

Start date

2024-05-15

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

Anesthetic Emergence:None

Sleep-Wake Transitions :None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1)Patients with primary Parkinson's disease who undergo bilateral subthalamic nucleus deep brain stimulation surgery under general anesthesia with etomidate, propofol, or remimazolam at our hospital; 2)No history of previous brain surgery; 3)Not taking antiparkinsonian medications before surgery; 4)Not taking sedative-hypnotic drugs before surgery; 5)Not taking antipsychotic drugs before surgery; 6)No intracranial hemorrhage during surgery; 7)Age between 18 and 80 years old.

Exclusion criteria

Exclusion criteria: 1)Patients who have undergone previous brain surgery; 2)Patients taking antiparkinsonian disease medications before surgery; 3)Patients taking sedative-hypnotic drugs before surgery; 4)Patients taking antipsychotic medications before surgery; 5)Patients with intracranial hemorrhage during surgery.

Design outcomes

Primary

Measure	Time frame
Characteristics of EEG-STN local field potential data;	—

Countries

China

Contacts

Public ContactNan Jiang

The First Affiliated Hospital of Sun Yat-sen University

jnan@mail.sysu.edu.cn+86 137 2540 7606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026