Nausea and vomiting
Conditions
Interventions
Experimental group:Aprepitant
Sponsors
Chongqing Changshou District People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1) Age >=18 years old; 2) Expect to receive surgical treatment; 3) Apfel risk simplicity score >=2 points; 4) Meet the American Society of Anesthesiologists (ASA) grading standards Level I-III; 5) The function of vital organs meets all the following requirements: a) Liver function: i.st, ALT and ALP= 60 mL/min (CrCl calculated according to Cockcroft-Gault formula) or serum creatinine <=1.5×ULN; 6) Subjects voluntarily participate in the study and are able to comply with treatment, periodic evaluation, follow-up and other requirements related to the study, and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) Pregnant or lactating women. 2) Patients with vomiting for any reason within 24 hours before surgery; 3) Received any antiemetic drugs (including but not limited to NK-1R antagonists, 5-HT3 receptor antagonists, corticosteroids (except for topical application), traditional Chinese medicine or proprietary Chinese medicine) or prophylactic antiemetic drugs within 1 week before enrollment. 4) The presence of any past or current medical conditions, treatments, or laboratory abnormalities that may confuse the study results, interfere with participants' full participation in the study, or that participation in the study may not be in the subjects' best interests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour complete response (CR) after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| 48-hour complete response (CR) after surgery;Proportion of patients without vomiting (with or without salvage therapy) in 24 and 48 hours after surgery;Proportion of patients received salvage therapy;time to treatment failure;safety; | — |
Countries
China
Contacts
Public ContactQi Jun
Chongqing Changshou District People's Hospital
Outcome results
None listed