idiopathic retroperitoneal fibrosis
Conditions
Interventions
Glucocorticoid combined with tamoxifen group:None
Sponsors
Department of Rheumatology and Immunology, Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients diagnosed with idiopathic retroperitoneal fibrosis confirmed by imaging and/or pathology; Aged >=18 years; Treatment-naïve patients (no prior treatment with glucocorticoids, immunosuppressants, tamoxifen, or biologics).
Exclusion criteria
Exclusion criteria: Presence of conditions potentially causing secondary retroperitoneal fibrosis, such as retroperitoneal tumors, history of abdominopelvic surgery or local radiotherapy, or certain medications; Coexisting autoimmune diseases; Uncontrolled chronic diseases, such as hypertension or diabetes; Inability to comply with follow-up, such as due to psychiatric disorders or intellectual disabilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission rate of clinical symptoms;Response rate of hydronephrosis;Response rate of retroperitoneal masses;Complete response rate; | — |
Countries
China
Contacts
Public ContactJuan Zhao
Department of Rheumatology and Immunology, Peking University First Hospital
Outcome results
None listed