thyroid gland
Conditions
Interventions
opioid-free group:opioid-free
opioid:opioid
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Han Chinese; 2.Age between 18 and 60 years; 3.American Society of Anesthesiologists (ASA) physical status I to III; 4.Had no history of chronic neurological or psychiatric disorders and medication abuse.
Exclusion criteria
Exclusion criteria: 1.Allergic to dexmedetomidine, esketamine or lidocaine; 2.current or previous drug or alcohol use disorder; 3.Long-term treatment with beta-blockers or HR = 5/hr; 6.body mass index >= 35 kg/m^2; 7.presence of serious heart problems, liver disease, kidney disease, infectious disease, endocrine problems; 8.women who were pregnant or in a breast feeding period; 9.Periodic limb movement (PLMS) during sleep >= 20/h; 10. Employed as a shift worker or have traveled across the clock in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality score on the first and third postoperative days (AIS score); | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep quality at 1 month postoperatively (Pittsburgh Sleep Quality Index Scale, PSQI);Sleep structure on the first night postoperatively;Patient's quality of recovery score on the first and third postoperative days (15-item Quality of Recovery Scale, QoR-15);Anxiety and depression scores on the first, third, and 30th postoperative days;rest and movement pain scores on postoperative day 1 , 3 and 30; | — |
Countries
China
Contacts
Public ContactJianjun Yang
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed