Adrenomyeloneuropathy
Conditions
Interventions
Test group:Spinal Cord Stimulation(SCS)
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
Male
Age
22 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Conforming to the diagnostic criteria of AMN, with a definite genetic testing report, and complicated by lower limb motor function disorders; 2. Age: 22-50 years old, male; 3. Capable of normal communication and able to complete scale tests independently (as determined by on-site scale tests); 4. Willing to participate in this study after giving informed consent; 5. The muscle tone of the patient's bilateral lower extremities was elevated.
Exclusion criteria
Exclusion criteria: 1.Other inherited diseases; 2.Other severe central nervous system diseases; 3.History of brain surgery; 4.Psychiatric and psychological diseases such as depression and anxiety; 5.The presence of metallic foreign bodies or prostheses (such as cardiac pacemakers, insulin pumps) in the body, claustrophobia, and other contraindications for MRI; 6.Informed consent was not obtained; 7.Unable to tolerate MRI-related examinations; 8.Received anticoagulant, antispasmodic or antiepileptic drug therapies throughout the entire study period; 9.Postoperative wound infection; 10.Other motor disorders, spinal cord pathologies, fractures, osteoarthritis, amputations, scoliosis and other movement-affecting diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| six minutes walk test.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Discomfort and pain.;Adverse event.;Spinal cord MRI;Stool scoring (Wexner Incontinence Scale, Bristol Stool Scale (BSFS));The degree of improvement in electrophysiological indicators of the muscles in the affected limbs.;Urodynamic examination;Evaluation of erectile function (International Index of Erectile Function-5 (IIEF-5) score);Somatosensory evoked potential, visual evoked potential, auditory evoked potential, motor evoked potential.;Motion capture (gait test);Short Physical Performance Battery (SPPB);Very-long-chain fatty acid (VLCFA) detection.;Cerebrospinal fluid (CSF) testing;Cranial MRI;Fugl-Meyer Assessment Scale of Motor Function; | — |
Countries
China
Contacts
Public ContactLiang Tan
The First Affiliated Hospital of Army Medical University
Outcome results
None listed