Overweight, obesity, pre-diabetes
Conditions
Interventions
Central obesity with pre-diabetes:Using doubly labeled water to measure total energy expenditure, using cardiopulmonary function tester to measure basal and resting metabolic energy expenditure, using
General overweight or obesity (non central obesity) with pre diabetes:Using doubly labeled water to measure total energy expenditure, using cardiopulmonary function tester to measure basal and resting
Healthy control (healthy population):Using doubly labeled water to measure total energy expenditure, using cardiopulmonary function tester to measure basal and resting metabolic energy expenditure, us
Sponsors
Guangdong Provincial Center for Disease Control and Prevention
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. BMI >=24, no significant change in body weight (within 3 months, fluctuation within 5%); 2. Those with light physical or moderate physical activity; 3. Regular life, willing to eat only the food provided during the participation period, no additional food and drink, and no alcohol; 4. Women are required to have regular menstruation (no menstruation will occur during the 10-day double-standard water experiment); 5. Willing to participate in the experiment and comply with the experimental requirements and management; 6. Among them, the waist circumference of men in the central obesity group >=90cm, and the waist circumference of women >=85cm; 7. Combined with prediabetes: fasting blood glucose [5.6, 7.0) mmol/L, and/or glycosylated hemoglobin [5.7, 6.5)%.
Exclusion criteria
Exclusion criteria: 1. Continuous strenuous physical activity for a period of time prior to enrollment; 2. Long-term use of any medication or dietary supplement that may affect the results of the study; 3. Heavy alcohol consumption; 4. Inability to comply with the prescribed diet; 5. Heavy manual laborers; 6. People with insomnia and easy nervousness; 7. Those whose liver function and kidney function are not in the normal range; 8. Digestive system diseases and metabolic system diseases. All participants were assessed by the Lingnan Dietary Questionnaire whether their daily dietary habits already belonged to the typical Lingnan dietary pattern, and if they were already in line with the typical Lingnan dietary pattern, they needed to be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total energy expenditure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basal and resting metabolic energy expenditure;Activity energy expenditure; | — |
Countries
China
Contacts
Public ContactDing Gangqiang
Guangdong Provincial Center for Disease Control and Prevention
Outcome results
None listed