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A non inferiority randomized controlled clinical study on the prevention of delayed platelet reconstruction after allogeneic hematopoietic stem cell transplantation using Hematide and rhTPO.

A non inferiority randomized controlled clinical study on the prevention of delayed platelet reconstruction after allogeneic hematopoietic stem cell transplantation using Hematide and rhTPO.

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094378
Enrollment
Unknown
Registered
2024-12-20
Start date
2024-08-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with hematological tumors

Interventions

Hematide group:Starting from the first day after transplantation, take 5mg/d Hematide on an empty stomach in the morning. For those who have been ineffective for 2 weeks, increase the dosage to 7.5mg/
rhTPO group:Starting from the first day after transplantation, rhTPO is injected subcutaneously at a dose of 15000 u/d until the platelet count rises to 50 × 109/L (maintained for 3 consecutive days w

Sponsors

Guangdong Provincial Hosipital of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=18 years old; 2. Patients with hematological tumors receiving allo HSCT treatment; 3. No use of rhTPO or non peptide TPO-RA prior to hematopoietic stem cell transplantation; 4. Those who agree to participate in this clinical study and sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Individuals who are allergic to research drugs and ingredients; 2. Patients with thromboembolic diseases that require treatment or those at high risk of developing thromboembolic diseases; 3. Merge severe organ dysfunction; 4. Patients currently participating in clinical trials of other drugs.

Design outcomes

Primary

MeasureTime frame
Platelet implantation rate;

Secondary

MeasureTime frame
The average time for platelet reconstruction;

Countries

China

Contacts

Public ContactYuanbin Wu

Guangdong Provincial Hosipital of Chinese Medicine

wuyuanbin1977@sohu.com+86 137 1145 4979

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026