witnessed cardiac arrest
Conditions
Interventions
OHCA:NA
Sponsors
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-75 years old; 2.OHCA witnessed by eyewitnesses; 3.Early first-aid patients performed cardiopulmonary resuscitation, and no blood flow time (CA to CPR time) was less than 5 minutes; 4.The initial heart rate was VF/pVT; 5. The cause of cardiac arrest is expected to be reversible; 6.The patient authorizes the client to sign the informed consent;
Exclusion criteria
Exclusion criteria: 1.Under 18 years of age or over 75 years of age,; 2.Known CPC score >3 before CA,; 3.Patients who do not have the conditions to complete femoral artery and vein catheterization; 4.Known or suspected pregnancy; 5.End-stage diseases, such as patients with malignant tumors, end-stage liver disease, kidney disease, severe heart failure (New York Heart Association dish or IV) or severe COPD(chronic obstructive pulmonary disease Global Obstructive Pulmonary Initiative standard is grade III or IV), ARDS, etc. 6.There are anticoagulation contraindications, such as active gastrointestinal or internal bleeding, aortic dissection, subarachnoid hemorrhage, severe trauma, etc. 7.Estimated low blood flow time (from CA to ECMO initiation time)>60min; There are two of the following scenarios. ETCO 18 mmol/L;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Structural imaging quantifies indicators of cerebral circulation, including vessel diameter, area, flow rate, velocity, and flow direction;Quantitative indicators of oxygenation imaging: arterial and venous blood oxygen, oxygen uptake rate, cerebral oxygen metabolism rate, hemoglobin concentration.;Local cerebral oxygen partial pressure;Lactic acid and pyruvic acid levels;Carotid artery and vein oxygen saturation, hemoglobin concentration, invasive blood pressure, blood gas indicators;Peak velocity, minute blood flow, and blood flow waveform of carotid artery; | — |
Countries
China
Contacts
Public ContactCong Mai
Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)
Outcome results
None listed