Major Depression Disorder
Conditions
Interventions
Personalized target Group:fMRI-guided Precision repeatitive transcranial magnetic stimulation
Traditional 5cm Methods Group:Traditional "5cm" method guided rTMS
Sham control group:Targeting the Cz point of the international 10-20 EEG electrode system
Sponsors
Institute for Brain Research and Rehabilitation
Eligibility
Sex/Gender
All
Age
12 Years to 24 Years
Inclusion criteria
Inclusion criteria: 1.Meeting the criteria of DSM-5 for major depressive disorder (MDD); 2.A total score =17 on HAMD-17; 3.A total score of the HCL-32=6; 7.No other physical therapy (electroconvulsive therapy, transcranial magnetic stimulation) within 6 months; 8.Agreed to participate in this study and signed an informed consent form;
Exclusion criteria
Exclusion criteria: 1.Diagnosed with mental illness other than depression; 2.A history of severe suicidal or self-injurious behavior; 3.A history of neurodegenerative diseases, such as Alzheimer's disease, Parkinson disease; 4.A combination of serious physical, infectious, or immune system disorders; 5.A history of organic brain disease, history of external brain injury, or history of surgery; 6.Persons with drug dependence or alcohol dependence within one year; 7.History of previous seizures;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep status;the changes of transcriptomic and epigenetic level;Negative automated thinking;Anhedonia;Sleep status;Cognitive function;suicidal idea;loneliness;Rumination;Mental Health status;Changes in Brain structure and function;safety; | — |
Countries
China
Contacts
Public ContactLijuan Huo
Institute for Brain Research and Rehabilitation
Outcome results
None listed