None
Conditions
Interventions
Experimental group:Ciprofol was induced and maintained under general anesthesia
Sponsors
department of Anesthesiology, General Hospital of the Southern Theater of the People's Liberation Army Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Ages 65 to 90; 2. Elective non-cardiac surgery patients under general anesthesia; 3. American Society of Anesthesiologists( ASA ) physical status classification I to III; 4. Informed consent, voluntary participation in the trial, and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe dysfunction of the heart, lungs, liver, or kidneys; 2. History of psychiatric disorders or long-term use of psychiatric medications (dementia, schizophrenia), chronic use of analgesics, or history of alcoholism; 3. Preoperative Short Portable Mental State Questionnaire (SPMSQ) with >= 8 errors, diagnosed as having severe cognitive impairment; 4. Any cerebrovascular accident within the past 3 months, such as stroke or transient ischemic attack; 5. Diabetic patients with severe complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy); 6. Patients with severe infections; 7. Preoperative arterial partial pressure of oxygen (PaO2) < 60 mmHg or pulse oxygen saturation (SpO2) < 92%; 8. Participation in another clinical drug trial within the past 6 months; 9. Language communication disorders, unable to complete cognitive function tests; 10. Allergy to the study drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative EEG characteristics ;The occurrence of postoperative POD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes during induction and maintenance of general anesthesia.;Operation and anesthesia time, wake up time;Postoperative recovery quality;Postoperative sleep quality;Perioperative adverse events such as hypotension, injection pain, bradycardia, and awakening agitation;Postoperative complication; | — |
Countries
China
Contacts
Public ContactXu Bo
Department of Anesthesiology, General Hospital of the Southern Theater of the People's Liberation Army Chinese People's Liberation Army
Outcome results
None listed