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Predictive Value and Mechanistic Study of Cerebrospinal Fluid Metabolomics Model in Postoperative Hydrocephalus Following Cerebral Hemorrhage

Predictive Value and Mechanistic Study of Cerebrospinal Fluid Metabolomics Model in Postoperative Hydrocephalus Following Cerebral Hemorrhage

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400094357
Enrollment
Unknown
Registered
2024-12-20
Start date
2024-12-31
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-hemorrhagic hydrocephalus

Interventions

Hydrocephalus group:None
Non-hydrocephalus group:None

Sponsors

Department of Neurosurgery, Zhongda Hospital, Affilicated of Southeast University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients over the age of 18 2. Patients with confirmed intracerebral hemorrhage, intraventricular hemorrhage, subarachnoid hemorrhage, or traumatic brain injury as determined by cranial CT or MRI, with complete demographic and clinical data. 3. Diagnosed with PHH within 3 months of follow-up: A. Evans index (maximum width of the frontal horn/maximum biparietal diameter at the same level) greater than 0.3; B. Enlargement of the anterior horn of the lateral ventricle, temporal horn, and third ventricle, along with periventricular interstitial edema; C. Presentation of PHH clinical symptoms: neurocognitive dysfunction in conscious patients (e.g., depression, decision-making difficulties, memory or language impairments), motor disturbances (unsteady gait, ataxia), and urinary or fecal incontinence; lack of improvement or worsening of consciousness in comatose patients, with hydrocephalus diagnosed via imaging (refer to the "Chinese Expert Consensus on the Standardized Treatment of Hydrocephalus (2013 Edition)" for specific diagnostic criteria). 4. No contraindications for lumbar puncture post-surgery, with the patient or legal representative signing the "Informed Consent for Lumbar Puncture". 5.The patient, or the patient's legally authorized representative, consents to participate in the research and signs the "Ethics Informed Consent Form".

Exclusion criteria

Exclusion criteria: 1. Minors under the age of 18, pregnant women, or lactating patients. 2. Patients with past or current comorbid central nervous system diseases, including but not limited to tumors, infections, or those in a decompressive craniectomy state. 3. Patients with dysfunction of systemic organs. 4. Patients who do not meet the PHH diagnostic criteria upon screening. 5. Patients who do not consent to undergo lumbar puncture or refuse to participate in this study.

Design outcomes

Primary

MeasureTime frame
Evans' ratio of ventricular size to cranial size;

Countries

China

Contacts

Public Contactlining

Zhongda Hospital, Affilicated of Southeast University

ningli.md@gmail.com+86 186 5161 5778

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026