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Application of exhaled breath detection and multi-omics methods to predict the prognosis of lung cancer after radiotherapy and chemotherapy and the incidence of radiation pneumonitis

Application of exhaled breath detection and multi-omics methods to predict the prognosis of lung cancer after radiotherapy and chemotherapy and the incidence of radiation pneumonitis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400094355
Enrollment
Unknown
Registered
2024-12-20
Start date
2024-08-26
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

RT group:No

Sponsors

Tianjin Medical University Cancer Institute and Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Sign the informed consent form. 2) Be aged 18 years or above and not more than 80 years old. 3) Have a KPS score of 70 or above and an expected survival period of more than 6 months. 4) Be histologically or pathologically diagnosed with lung malignancy. 5) The planned radiotherapy site has not received radiotherapy before or it has been more than 6 months since the last radiotherapy. 6) Be able to complete radiotherapy and have follow-up conditions.

Exclusion criteria

Exclusion criteria: 1) Patients with chronic obstructive pulmonary disease. 2) Patients with metabolic comorbidities (such as obesity, dyslipidemia, etc.) and respiratory disorders (such as poorly controlled diabetes). 3) Patients with other serious diseases who cannot complete treatment or have an expected survival period of less than 3 months. 4) Currently having active tuberculosis or having infections such as pneumonia. 5) Pregnant or lactating patients. 6) Patients with a known history of human immunodeficiency virus (HIV) infection. 7) Patients who have received solid organ or hematopoietic system transplantation. 8) Currently participating in other clinical trials or having participated within 4 weeks. 9) Other situations where the reviewer deems there are sufficient reasons to be unqualified from the registered study: such as potential situations that do not conform to the clinical protocol.

Design outcomes

Primary

MeasureTime frame
efficacy evaluation;radiation pneumonitis;

Secondary

MeasureTime frame
Progression Free Survival;Overall Survival;haematotoxicity;

Countries

China

Contacts

Public ContactZhao Lujun

Tianjin Medical University Cancer Institute and Hospital

zhaolujun@tjmuch.com+86 131 0225 8620

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026