patients with first-episode and untreated depression
Conditions
Interventions
First-Episode Depression Group:None
Healthy Control Group:None
Sponsors
Shandong Daizhuang Hospital
Eligibility
Sex/Gender
All
Age
13 Years to 55 Years
Inclusion criteria
Inclusion criteria: Depression Group: (1) Meet the diagnostic criteria for depression through structured clinical interview (SCID-V); (2) Age between 13 to 55 years old, right-handed, Han ethnicity; (3) Score of over 20 on the Hamilton Depression Scale (HAMD-24); (4) IQ > 90 (Wechsler Intelligence Scale); (5) Voluntarily accept fMRI examination. Healthy Control Group: (1) In good health, with no disorders meeting the DSM-5 Axis I diagnostic criteria upon SCID screening; (2) No history of mental illness; (3) No current severe physical illnesses; (4) Age between 13 to 55 years old, right-handed, Han ethnicity; (5) Capable of cooperating to complete the project assessments; (6) Matched with the patient group in terms of age, gender, and education level; (7) IQ > 90 (Wechsler Intelligence Scale); (8) Intact social functioning (able to work or study normally, not retired due to illness), with full capacity for action and responsibility.
Exclusion criteria
Exclusion criteria: Depression Disorder Group: (1) History of substance dependence; history of mental disorders that meet the SCID Axis I diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (3) Contraindications for MRI examination; (4) Pregnant or breastfeeding patients; (5) Family history or personal history of epilepsy. Healthy Control Group: (1) History of substance dependence; history of any mental disorders that meet the SCID Axis I or II diagnostic criteria; history of brain trauma, epilepsy, or other organic brain diseases; (2) History of loss of consciousness; (3) Positive family history of mental illness in two generations and three degrees; (4) History of taking antipsychotic or antidepressant medications; use of benzodiazepines or other central nervous system affecting drugs within one month before MRI; continuous medication treatment within the past 6 months; (5) Uncooperative in testing or unable to effectively complete tests; (6) Laboratory tests indicate liver or kidney dysfunction or other severe physical diseases and metabolic disorders; (7) Contraindications for MRI examination; (8) Pregnant or breastfeeding patients; (9) Color blindness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-Item Hamilton Rating Scale for Depression Srcoe;Functional magnetic resonance imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale Srcoe;Positive and Negative Syndrome Srcoe;Hypomania Check List Srcoe;Pittsburgh sleep quality index;Life Event Scale Srcoe;Childhood Trauma Questionnaire;Snaith-Hamilton Pleasure Scale Srcoe;Sheehan Disability Scale Srcoe;Ottawa Self-injury Inventory Srcoe;Self-Rating Depression Scale Srcoe;Self-Rating Anxiety Scale Srcoe;Beck Scale for Suicide Ideation Srcoe;Toronto Alexithymia scale Srcoe;Patient Health Questionnaire-15 Srcoe;Cognitive Scale Srcoe; | — |
Countries
China
Contacts
Public ContactKun Li
Shandong Daizhuang Hospital
Outcome results
None listed