The effects of anesthetic drugs on the body
Conditions
Interventions
Cyclopofol group:Intravenous injection of cyclosporine 0.4mg/kg
Propofol group:intravenous injection of propofol 2mg/kg
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1)Observation age 22~45 years old; 2)female; 3) ASAI~II; 4) height 150~170cm; 5)body mass index 18~28kg/m²; 6)planned to perform surgery under general anesthesia.
Exclusion criteria
Exclusion criteria: 1) Recent use of any medications that affect vasotonia (e.g., vasoactive medications, calcium channel blockers, or angiotensin-converting enzyme inhibitors); 2) cardiovascular or peripheral vascular disease (e.g., Raynaud syndrome); 3) medications that may affect the sympathetic or parasympathetic nerves (e.g., anticholinergics or ß-blockers); 4) diabetes mellitus, neurological or psychiatric disorders, history of substance abuse, history of anxiety or depression; 5) monitoring fingers for nail polish; 6) anemia, electrolyte acid-base imbalance; 7) abnormal body temperature or hand temperature.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perfusion index (PI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;pulse; | — |
Countries
China
Contacts
Public ContactJi Leting
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed