Coats' disease
Conditions
Interventions
Ozurdex with laser therapy group:intra-vitreal injection of Ozurdex and combined with laser therapy
Ranibizumab with laser therapy group:intra-vitreal injection of ranibizumab and combined with laser therapy
Sponsors
Eye and ENT Hospital, Shanghai Medical College, Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with severe type Coats' disease: Patients in stage 2B with exudation involving more than two quadrants, and patients in stages 3A and 3B. 2. Patients and their families must be able to provide a signed informed consent form, voluntarily participate in the study; and be able to comply with all research procedures and assessments during the study period.
Exclusion criteria
Exclusion criteria: Patients who meet any of the following criteria will not be eligible for inclusion in this study. To ensure that the study population represents all eligible patients, investigators shall not apply additional exclusion criteria: 1. Women who are pregnant or breastfeeding; 2. A history of stroke, cerebral infarction, peripheral vascular disease, angina, or myocardial infarction within the 6 months prior to the screening period; 3. Received ocular corticosteroids, any type of anti-vascular endothelial growth factor (anti-VEGF) drugs, or undergone any other ocular surgery within the 3 months prior to the screening period; 4. Uncontrolled glaucoma (IOP of 21mmHg or higher), neovascularization of the iris, or neovascular glaucoma in either eye at the time of screening or baseline; 5. Active infectious diseases in either eye at the time of enrollment, or intraocular inflammation, active or suspected periocular infection; 6. Patients who are unable to comply with the study or follow-up procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best corrected visual acuity;The rate of retinal abnormal vascular regression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Change of foveal thickness;Frequency of intra-vitreal injections;The rate of subretinal exudation absorption;The rate of disease progression ;The frequency of retinal laser therapy; | — |
Countries
China
Contacts
Public ContactXin Huang
Eye and ENT Hospital, Shanghai Medical College, Fudan University
Outcome results
None listed