Postoperative analgesia after TKA
Conditions
Interventions
Test group (bupivacaine liposome protocol):Bupivacaine liposomal for adductor canal block and periarticular infiltrate
Control group (Ropivacaine group): Ropivacaine for adductor canal block and periarticular infiltrate
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing initial unilateral total knee replacement for osteoarthritis of the knee; 2.Age: 18 to 80 years old. 3. BMI: 18-28 kg/m^2; 4.American Society of Anesthesiologists (ASA) class I to III; 5. Willing to sign informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with bilateral, revision knee replacements; 2.Patients with non-osteoarthritis, such as rheumatoid arthritis and traumatic arthritis; 3. Patients who are allergic to various anaesthetic drugs; 4. Abnormal blood clotting time and platelet count; 5.Pre-operative presence of cognitive dysfunction; 6.Unwilling to sign informed consent.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Opioids consumption;Length of hospital stay;Sleep quality;Joint mobility;Drug adverse reaction(Cardiac toxicity);Functional evaluation of the knee;VAS pain score of exercise at other time points postoperatively;Drug cost; | — |
Primary
| Measure | Time frame |
|---|---|
| VAS pain score of exercise on 48 h postoperatively; | — |
Countries
China
Contacts
Public ContactYunchao Shao
Zhongshan Hospital, Fudan University
Outcome results
None listed