Pulmonary nodule
Conditions
Interventions
Acetaminophen mannitol injection group:Acetaminophen mannitol injection was injected intravenously 15 minutes before the operation began and 15 minutes after the injection was completed
Normal saline group:Normal saline was injected intravenously 15 minutes before the operation and 15 minutes after the infusion
Sponsors
Chengdu Jinniu District People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age =18 years old, gender unlimited; 2) ASA I-II level; 3) Patients who plan to undergo elective thoracoscopic pulmonary resection under bronchial intubation general anesthesia; 4) Sign informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1) History of allergy to acetaminophen; 2) A known or suspected history of opioid intolerance; 3) A history of chronic pain or use of opioids or other pain modulators within the previous 2 weeks; 4) End-stage renal disease; 5) End-stage liver disease; 6) Severe depression or anxiety; 7) Seizures; 8) Known or suspected history of alcohol or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total dosage of sufentanil within 24 h after first administration;NRS scores during exercise 24 hours after surgery;TNF-a;CRP;IL-6; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative adverse reactions;Postoperative related complications; | — |
Countries
China
Contacts
Public ContactZhu Li
Chengdu Jinniu District People's Hospital
Outcome results
None listed