Perioperative cognitive dysfunction
Conditions
Interventions
Sleep disorders Group1:normal saline
Sleep disorders Group2:Dexmedetomidine
Non Sleep disorders Group1 :normal saline
Non Sleep disorders Group2:Dexmedetomidine
Sponsors
Affiliated Hospital of North China University of Science and Technology
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Age >=65 years old; 2.ASA physical status I-III; 3.Scheduled to undergo surgical treatment of hip fractures and intraspinal anesthesia; 4.Preoperative cognitive function assessment is normal.
Exclusion criteria
Exclusion criteria: 1.Severe cardiopulmonary, liver and kidney dysfunction or severe immune system disease; 2.Had a history of stroke or any other central nervous system disease within 6 months; 3.Had a history of schizophrenia, epilepsy, Parkinsonism, myasthenia gravis or other mental illness; 4.Alcoholism or history of psychotropic substance dependence; 5.Inability to communicate because of severe visual, auditory or verbal problems; 6.Refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative alteration of cognitive function;Recombinant S100 Calcium Binding Protein B;Neuron-Specific Enolase;Neurofilament light chain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin-6; Interleukin-1ß;Tumor necrosis factor-a ; | — |
Countries
China
Contacts
Public ContactZhang Shubo
Affiliated Hospital of North China University of Science and Technology
Outcome results
None listed