The effect of esketamine on improving perioperative anxiety and depression in elderly patients undergoing pelvic floor surgery: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400094297

Enrollment

Unknown

Registered

2024-12-19

Start date

2024-12-23

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peroperative anxiety and depression in elderly pelvic floor disease

Interventions

Intervention group:Perioperative intravenous esketamine

Control group:The same dose of normal saline was applied during the perioperative time

Eligibility

Sex/Gender

Female

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: Eligible participants include elderly famale patients( Age>=60 years) with an ASA physical status of I to III, scheduled for elective pelvic floor surgery and could sign informed consent;

Exclusion criteria

Exclusion criteria: 1.Allergy to esketamine;2.psychiatric illness, bipolar disorder and recurrent depression;3.use of antidepressant medication within 2 weeks before admission;4.patients with postoperative ICU admission;5.hyperthyroidism, intracranial hypertension, glaucoma;6.patients enrolled in other studies;

Design outcomes

Primary

Measure	Time frame
The Hamilton Depression Score;	—

Secondary

Measure	Time frame
NRS(Numerical Rating Scale) score;Postoperative hospital stay;Total cost of hospitalization;The Hamilton Anxiety Score;Security indicators;vital signs;	—

Countries

China

Contacts

Public ContactHan Huang

West China Second Hospital, Sichuan University

han.huang@scu.edu.cn+86 181 8060 9889

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026