Postoperative Delirium
Conditions
Interventions
Dexmedetomidine group:Dexmedetomidine hydrochloride nasal spray (1ml:500ug) was given to patients in DEX group from 20:30 to 21:30 on the day before surgery. One spray was injected into each side of t
Control group:Control group was given equal volume 3 injection of normal saline from 20:30 to 21:30 the day before surgery
Sponsors
The First Affiliated Hospital of Hebei North University
Eligibility
Sex/Gender
All
Age
65 Years to 79 Years
Inclusion criteria
Inclusion criteria: (1) Age 65~79 years old; (2) ASA LEVELS I-III; (3) BMI 11; (6) All patients and their families signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients who are unable to sign the informed consent form; (2) Patients who do not understand Chinese; (3) Severe respiratory disease or cardiovascular disease; (4) Severe liver disease (Childs-Pugh score class C); (5) Severe audio-visual impairment affecting communication; (6) Patients with dementia or the score of the preoperative Mini-mental state examination (MMSE) is lower than the minimum score of the corresponding education level (17 points for illiterate >, 20 points for primary school >, and 24 points > middle school or above); (7) Patients receiving psychotropic medication before surgery; (8) Patients with a history of alcohol consumption who received a score of 15 points on the Alcohol Use Disorders Identification Test (AUDIT) > 15 points; (9) History of previous nasal surgery or diseases affecting nasal administration; (10) Allergy or contraindication to the study drug; (11) Those who could not have postoperative follow-up; (12) Severe bradycardia, second-degree/third-degree atrioventricular block; (13) Patients with severe snoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium during recovery from anesthesia;Incidence of delirium ;Operation duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ramsay score ;From the time of administration of dexmedetomidine or saline until Ramsay score >=3;HR and MAP;Anesthesia duration;Extubation duration;Duration of stay in PACU;Use of vasoactive drugs;Use of narcotic drugs;Sedation and agitation score during waking period;Pain score 10min after extubation and 12h and 24h after extubation;Anxiety scores 1 day before surgery and at 7:00 on the day of surgery (before surgery);Recovery quality scores of patients ;The level of interleukin-6 in venous blood ;neurofilament light (NfL) levels in venous blood;The level of phosphorylated neurofilament heavy subunit -H in venous blood;The number of consecutive 1-minute episodes of hypotension/hypertension during the operation;Incidence of postoperative nausea and vomiting;Incidence of postoperative dizziness;The number of intraoperative bradycardia (heart rate < 50 beats /min);Anesthesia recovery time; | — |
Countries
China
Contacts
Public ContactYao Jie; Zhang Yuxi
The First Affiliated Hospital of Hebei North University
Outcome results
None listed