Knee osteoarthritis
Conditions
Interventions
PRP group:Intra-articular injections of PRP
HA group:Intra-articular injections of HA
Sponsors
Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) be aged between 18 and 80 years; 2) be able to provide informed consent; 3) a visual analogue pain score of at least 40 points (100 is the worst pain) on 7 days a week in the past month; 4) radiographic diagnosis of OA; 5) Osteoarthritis was graded as 1-4 according to Kellgren-Lawrence (K-L) classification; 6) The symptoms occurred unilaterally
Exclusion criteria
Exclusion criteria: 1) knee instability; 2) Visual analogue scale pain score less than 40; 3) large force line irregularity (>5°); 4) bilateral symptomatic lesions; 5) systemic diseases such as diabetes mellitus, rheumatoid arthritis, blood disorders (coagulopathy), severe cardiovascular disease, infection or immunodeficiency; 6) use of anticoagulants or non-steroidal anti-inflammatory drugs within 5 days before blood transfusion; 7) known history of anemia; 8) a recent (within 30 days) articular corticosteroid injection and treatment with hyaluronic acid within the past 6 months; 9) pregnancy or potential pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC pain score (change); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score (change);WOMAC function score (change);KL grade score (change);Cartilage thickness on MRI; | — |
Countries
China
Contacts
Public ContactCai Qianying
Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed