Pancreatic space occupying lesions
Conditions
Interventions
Bupivacaine liposomes+patient-controlled analgesia group(Group LB+IVPCA):Bupivacaine liposome incision local infiltration anesthesia combined with postoperative patient-controlled analgesia pump
Bupivacaine hydrochloride+patient-controlled analgesia group(Group B+IVPCA):Hydrochloric acid bupivacaine incision local infiltration anesthesia combined with postoperative patient-controlled analgesi
Patient-controlled analgesia group(Group IVPCA):Only use patient-controlled analgesia pump after surgery
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18-65 years old, ASA grade I.-III., who were scheduled to undergo pancreaticoduodenectomy under general anesthesia, were randomly selected for treatment in Jiangsu Provincial People's Hospital.
Exclusion criteria
Exclusion criteria: 1) Obvious abnormalities in liver function (AST or ALT> 2.5 ×upper limit of normal); 2) abnormal renal function (serum creatinine >2 mg/dl); 3) Severe cardiovascular disease; 4) allergy to the study drug; 5) Patients with low albumin level and cachexia who are prone to local anesthetic toxicity; 6) Patients with intellectual disabilities, mental disorders, and other physiological and pathological conditions that affect communication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical wound assessment tool with scoring;Hollander wound evaluation score (HWES); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score at rest and on coughing;The number of presses of the patient-controlled analgesia pump;Postoperative length of hospital stay;Cumulative consumption of morphine during the perioperative period;Drug-related complication rate;First exhaust time; | — |
Countries
China
Contacts
Public ContactMingfeng He
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed