Pharmacodynamic study of sedative drugs induced changes in consciousness
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. 40 healthy subjects aged 18-45 years old; 2. BMI between 18-26; 3. American Society of anesthesiologists (ASA) grade I; 4. Understand and voluntarily participate in the study, and sign the informed consent form by himself;
Exclusion criteria
Exclusion criteria: 1. Drug abuse or alcohol abuse; 2. Have psychiatric or neurological diseases or medical history; 3. Allergy to propofol or other emulsion injections; 4. History of cardiovascular, respiratory, renal, hepatic, gastrointestinal diseases or major surgery; 5. Participated in other clinical trials in the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Observer"s Assessment of Alertness/Sedation, MOAA/S; | — |
Countries
China
Contacts
Public ContactYaomin Zhu
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed