coronary artery disease
Conditions
Interventions
Gold Standard:The second part: Myocardial blood flow values by 13N-NH3 PET/CT.
The third part: Hemodynamically obstructive CAD was defined as high-grade stenosis (>90% diameter stenosis) by visual ass
Index test:rest myocardial blood flow, stress myocardial blood flow, myocardial blood flow reserve
Sponsors
Chinese Academy of Medical Sciences & Fuwai Hospital, National Center for Cardiovascular Diseases
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: This project consists of four parts. The first part will use retrospective data and does not involve inclusion criteria. The second part: Patients with known or suspected CAD who are scheduled for clinically indicated SPECT myocardial perfusion imaging. The third part: 1. Angina symptoms such as chest tightness and pain; 2. At least one coronary stenosis =50% in CTA. The forth part: Patients with known or suspected CAD who are scheduled for clinically indicated SPECT myocardial perfusion imaging
Exclusion criteria
Exclusion criteria: This project consists of four parts. The first part will use retrospective data and does not involve exclusion criteria. The second part: 1. Contraindication for adenosine stress test; 2. Pregnant or breastfeeding; 3. Not agree to sign consent form. The third part: 1. prior revascularization including coronary artery bypass grafting and percutaneous coronary intervention within 6 months; 2. Nonischemic cardiomyopathy or LVEF<35%; 3. Contraindication for adenosine stress test; 4. Pregnant or breastfeeding; 5. Not agree to sign consent form. The forth part: 1. Contraindication for adenosine stress test; 2. Pregnant or breastfeeding; 3. Not agree to sign consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| myocardial blood flow;myocardial flow reserve;coronary stenosis;fractional flow reserve;Accuracy;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Positive predicative value;Negative predictive value; | — |
Countries
China
Contacts
Public ContactLei Wang
Chinese Academy of Medical Sciences & Fuwai Hospital, National Center for Cardiovascular Diseases
Outcome results
None listed