Short stature
Conditions
Interventions
Prepubertal children of short stature :Different Initial doses of PEG-rhGH
Pubertal children of short stature :Different Initial doses of PEG-rhGH with or without GnRHa treatment
Sponsors
Department of Pediatric Genetic Metabolic Endorinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
1 Years to 16 Years
Inclusion criteria
Inclusion criteria: (1) Patients with short stature or a genetic target height below 2 standard deviations; (2) Individuals who are pre-pubertal (Tanner stage I) and pubertal (Tanner stages II-IV). (3) Legal guardians consenting to participate in the study and signing informed consent forms.
Exclusion criteria
Exclusion criteria: (1) Known or suspected hypersensitivity reactions to the investigational product or related products; (2) Presence of severe systemic diseases; (3) Patients with malignant tumors; (4) Participation in any other clinical trial and receipt of drug or non-drug interventions within the 3 months prior to screening; (5) Patients unable to adhere to follow-up or receive treatment as scheduled; (6) Other circumstances in which the investigator deems the patient unsuitable for inclusion in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height growth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sexual development status ;Bone age; | — |
Countries
China
Contacts
Public ContactShan Xiaoou
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed