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Evaluating the effectiveness of a combined letrozole ovulation induction regimen in in vitro fertilization and embryo transfer in patients with polycystic ovary syndrome: a single-center, open-label, single-arm superiority clinical study

Evaluating the effectiveness of a combined letrozole ovulation induction regimen in in vitro fertilization and embryo transfer in patients with polycystic ovary syndrome: a single-center, open-label, single-arm superiority clinical study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094242
Enrollment
Unknown
Registered
2024-12-19
Start date
2024-08-02
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovarian syndrome

Interventions

LE group:GnRH antagonist protocol with letrozole

Sponsors

Sun Yat-sen Memorial Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Women under 42 years old; 2. Medical indications for IVF/ICSI treatment, undergoing IVF/ICSI for the first or second time; 3. Women diagnosed with PCOS according to the Rotterdam criteria; 4. Written informed consent obtained.

Exclusion criteria

Exclusion criteria: 1. Recurrent implantation failure (3 or more previous IVF/ICSI-ET failures); 2. Untreated endometrial disease; 3. Hydrosalpinx without surgical correction; 4. Diagnosis of endometriosis (Stage III or IV); 5. Use of donor oocytes for conception; 6. Undergoing preimplantation genetic testing; 7. History of recurrent spontaneous miscarriage.

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate per ovulation induction cycle;

Secondary

MeasureTime frame
Normal fertilization rate;Cleavage rate;Usable embryo rate;High-quality embryo rate;Fresh embryo transfer rate;Embryo implantation rate;Miscarriage rate;

Countries

China

Contacts

Public ContactLinlin Jiang

Sun Yat-sen Memorial Hospital of Sun Yat-sen University

jlinl@mail2.sysu.edu.cn+86 135 7020 4289

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026