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Comprehensive Analysis of the Mechanisms Underlying the Potentiation of PD-1 Inhibitor Efficacy through Vaccination with ITGB2-Derived Neoantigens

Investigation into the Mechanistic Underpinnings and Therapeutic Implications of MHC Class II-Restricted Tumor Neoantigen ITGB2 in Augmenting the Efficacy of PD-1 Blockade by Engaging CD4+ T Cells

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400094237
Enrollment
Unknown
Registered
2024-12-19
Start date
2024-12-31
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

Observation group:None

Sponsors

Sichuan Cancer Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Subjects voluntarily joined the study, signed the informed consent form, had good compliance, and cooperated with follow-up; 2. Age>=18 years old (calculated on the day of signing informed consent), both male and female; 3. Have at least one measurable lesion according to RECIST1.1 criteria; 4. ECOG physical state score 2 points, ASA score 3 points; 5. No other malignant tumors have occurred within five years.

Exclusion criteria

Exclusion criteria: 1. The examination showed that fibrolamellar HCC, sarcomatoid HCC or mixed cholangiocarcinoma. Liver transplant status or history of active autoimmune disease; 2. The patient has other serious comorbidities: such as severe cardiopulmonary diseases, cardiac function below clinical grade 2, pulmonary sensibilities, moderate to severe COPD, chronic bronchiitis, etc., severe diabetes and/or renal insufficiency, severe malnutrition, etc.; 3. Pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
ITGB2 expression level;

Secondary

MeasureTime frame
Progression-free survival (PFS);Overall Survival (OS);

Countries

China

Contacts

Public ContactHuang Xiaolun

Sichuan Cancer Hospital

huangxiaolun@med.uestc.edu.cn+86 28 85420691

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026