Individualized Neuroregulation Intervention Techniques for Core Clinical Features of Drug Addiction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400094220

Enrollment

Unknown

Registered

2024-12-18

Start date

2024-12-25

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Methamphetamine dependence

Interventions

Closed-loop tACS stimulation group:Receive closed-loop tACS intervention, with the stimulation site on the left dorsolateral prefrontal cortex (DLPFC), stimulation intensity of 2mA, stimulation freque

Traditional open-loop tACS stimulation group:Receive open-loop tACS stimulation with fixed parameters and stimulation duration, 5 sessions per week, lasting for 4 weeks, with a total of 20 stimulation

Sham stimulation group:It is like a placebo, as it does not actually provide treatment.

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Meet DSM-5 (The Diagnostic and Statistical Manual of Mental Disorders-5) diagnostic criteria for methamphetamine use disorder; Age 18-45 years.

Exclusion criteria

Exclusion criteria: a. Severe cognitive dysfunction, such as history of head trauma, cerebrovascular disease, epilepsy, etc., and have used drugs to promote cognitive function in the past 6 months; b. DSM-5 diagnosis of schizophrenia or other severe mental illness; c. Severe organic diseases; d. Contraindications to tACS (e.g., history of seizures, metal implants near the head).

Design outcomes

Primary

Measure	Time frame
The reduction rate of each subscale score on the Visual Analog Scale for Psychological Craving before and after the intervention.;Other exploratory indicators;	—

Secondary

Measure	Time frame
The reduction rate of each subscale score on the Cogstate cognitive function assessment tool before and after the intervention.;The reduction rate of each item score on the Beck Depression Inventory (BDI) before and after the intervention.;The reduction rate of each item score on the Beck Anxiety Inventory (BAI) before and after the intervention.;The reduction rate of the scores on the Balloon Analogue Risk Task (BART) before and after the intervention.;The reduction rate of the scores on the Go/NoGo task before and after the intervention.;The change in blood pressure values.;Skin conductance;Electroencephalography (EEG);Imaging indicators (fMRI);Biological indicators;	—

Measure

Time frame

The reduction rate of each subscale score on the Cogstate cognitive function assessment tool before and after the intervention.;The reduction rate of each item score on the Beck Depression Inventory (BDI) before and after the intervention.;The reduction rate of each item score on the Beck Anxiety Inventory (BAI) before and after the intervention.;The reduction rate of the scores on the Balloon Analogue Risk Task (BART) before and after the intervention.;The reduction rate of the scores on the Go/NoGo task before and after the intervention.;The change in blood pressure values.;Skin conductance;Electroencephalography (EEG);Imaging indicators (fMRI);Biological indicators;

—

Countries

China

Contacts

Public ContactPing Dong

Peking University Sixth Hospital

dongping200801@163.com+86 131 2178 4900

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026