hypertension
Conditions
Interventions
Dexmedetomidine nasal spray low dose group:3 sprays of dexmedetomidine nasal spray and 1 spray of normal saline were administered nasal
Dexmedetomidine nasal spray high dose group:Give dexmedetomidine nasal spray 4 sprays
Ropivacaine surface anesthesia group:After the effect of anesthesia induced muscle release, 3ml 0.75% ropivacaine was used to perform uniform surface anesthesia in the epiglottis, subglottic trachea,
Sponsors
The Fourth Affiliated Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Voluntarily participate in and cooperate with this experimental study; (2) Age 18~70 years old, ASA grade I~?; (3) The operation should be performed under endotracheal intubation.
Exclusion criteria
Exclusion criteria: (1) People suffering from severe mental illness and speech communication disorders; (2) recent or long-term use of sedatives and psychotropic drugs; (3) Patients with serious nasal disorders that affect drug absorption; (4) Patients with hypertension who do not take medication regularly; (5) Patients requiring muscle relaxant antagonists during recovery; (6) Patients with advanced heart block and/or severe cardiac insufficiency; (7) Patients with previous myocardial infarction, unstable angina pectoris, severe arrhythmia, and cardiac insufficiency; (8) Patients with severe asthma, severe emphysema, severe bronchitis, severe chronic obstructive pulmonary disease, obstructive sleep apnea syndrome; (9) Patients with liver insufficiency; (10) Pregnant or lactating women (11) patients allergic to dexmedetomidine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate;systolic blood pressure;diastolic blood pressure;mean arterial pressure; | — |
Countries
China
Contacts
Public ContactTian Ayong
The Fourth Affiliated Hospital of China Medical University
Outcome results
None listed