Lupus nephritis
Conditions
Interventions
Gold Standard:Renal Biopsy and Histopathology
Index test:Conventional ultrasound, two-dimensional shear wave elastography, and contrast-enhanced ultrasound
Sponsors
Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Body mass index between 18.5 and 27.9; 3.Clinically diagnosed as SLE; 4.Elevated serum creatinine levels or elevated urine protein levels; 5.No history of prior kidney surgery;
Exclusion criteria
Exclusion criteria: 1.Allergy to contrast agents; 2.Patients with non-LN related pathology, congenital kidney abnormalities, or renal tumors; 3.Severe cardiopulmonary dysfunction, such as acute coronary syndrome or clinically unstable ischemic heart disease, including progressive or ongoing myocardial infarction; acute heart failure, heart failure classified as NYHA class III/IV; severe arrhythmias, and pulmonary embolism, etc. 4.Pregnancy and breastfeeding; 5.Renal artery stenosis or the presence of intrarenal arteriovenous fistula; 6.Patients with contraindications to kidney biopsy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal ultrasound parameters; | — |
Countries
China
Contacts
Public ContactWei Shuping
Drum Tower Hospital
Outcome results
None listed