Schizophrenia
Conditions
Interventions
Interventional group:TI intervention was received with the target area of the right nucleus accumbens.
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 65 years (inclusive), no gender restriction; 2. Diagnosed with schizophrenia by a research physician according to the *Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition* (DSM-5), with no restriction on whether it is the first episode or a recurrence; 3. A score of 20 or higher on the Negative Symptom Subscale of the Positive and Negative Syndrome Scale (PANSS); 4. Schizophrenia treatment regimen remains unchanged within 30 days prior to signing the informed consent and during the trial period; 5. The participant possesses basic listening, speaking, reading, writing, and comprehension abilities to complete the study assessments; 6. Based on the research physician's judgment, the participant understands the purpose and procedures of the study, can comply with the protocol requirements, and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with a history of other psychiatric disorders, neurological disorders, or substance abuse that, in the judgment of the investigator, may affect the evaluation of treatment efficacy; 2. Individuals with a history of epilepsy or previous seizure-like convulsions; 3. Individuals with metallic foreign objects in the skull or metallic implants in the heart; 4. Those with organic brain diseases or a history of severe head trauma or head surgery; 5. Individuals who have undergone electroconvulsive therapy or other physical treatments (e.g., transcranial magnetic stimulation, transcranial electrical stimulation) in the last 30 days; 6. Individuals scoring 3 or higher on the suicide item of the 17-item Hamilton Depression Scale (HAMD-17); 7. Individuals currently pregnant, breastfeeding, or planning to conceive during the trial period; 8. Individuals participating in other clinical interventional trials; 9. Other conditions deemed unsuitable for the study intervention by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Negative symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| Life quality;Cognitive function;Positive symptoms;Depression and anxiety symptoms;Side effects;Other functional indicators; | — |
Countries
China
Contacts
Public ContactLi Shen
Tianjin Anding Hospital
Outcome results
None listed