articular cartilage injury
Conditions
Sponsors
Xi’an Honghui Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1) Gender not limited, aged 18-55, in good physical condition, able to tolerate surgery; 2) According to the Outerbridge criteria for injury diagnosis, cartilage injuries are classified as grade III and IV; 3) MRI evaluation shows that the patient has a large area (1-4cm ²) of cartilage defect, 4) No obvious joint degeneration or extra articular deformities; 5) Informed consent: Participants must have the ability to understand and voluntarily sign written informed consent, comply with the research protocol and visit procedures;
Exclusion criteria
Exclusion criteria: 1) Patients with stage three or more knee osteoarthritis, inversion angle exceeding 10 degrees, or bilateral ventricular lesions; 2) MRI indicates severe subchondral bone injury combined with severe ipsilateral meniscus injury, requiring complete meniscectomy; 3) Allergic constitution, such as a history of autoimmune diseases or family history; 4) Patients who have received bone marrow mesenchymal stem cell transplantation for cartilage defects in the affected knee joint within 12 months before surgery, or He underwent cartilage regeneration surgery; 5) Knee cartilage injury is caused by joint fractures, infections, tumors, and immune diseases; 6) Systemic infection, including HIV, hepatitis B, hepatitis C, human T-cell lymphoma virus and syphilis; 7) Patients with knee joint tumors, rheumatism, rheumatoid arthritis, tuberculosis, suppuration, and complications that affect joint structure; 8) Secondary knee arthritis accompanied by psoriasis, syphilitic neuropathy, and metabolic bone disease; 9) Individuals who frequently use sedatives, sleeping pills, tranquilizers, or other addictive drugs; 10) Patients with severe primary diseases such as cardiovascular, cerebrovascular, hepatic, renal, and hematopoietic systems, as well as psychiatric disorders; 11) Those who cannot accept long-term and complicated rehabilitation training after surgery; 12) Women within 12 months of family planning, breastfeeding, and pregnancy; 13) Patients with special beliefs, sourced from pig sources; 14) Other doctors consider it unsuitable;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MR;Lysholm Knee Function Score ; | — |
Secondary
| Measure | Time frame |
|---|---|
| MR;Knee Joint Functional Score (IKDC);Pain score(VAS);Tegner score ;Operational satisfaction;Safety evaluation indicators; | — |
Countries
China
Contacts
Public ContactZheng Jiang
Xi’an Honghui Hospital
Outcome results
None listed