Glaucoma patients with high intraocular pressure
Conditions
Interventions
group C:Saline nasal spray
Group D:Dexmedetomidine nasal spray
Sponsors
Henan Provincial People's Hospita,medical
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age 18-65 years old; 2) ASA ?~ II; 3) BMI 18.5~29.9; 4) HR>60 bpm, Bp50%; 5) Glaucoma patients with high IOP > 21 mmHg and surgical treatment; 6) The cornea was found normal by slit-lamp examination; 7) Accept the clinical study protocol and sign the informed consent;
Exclusion criteria
Exclusion criteria: 1) Diabetic patients; 2) Systemic or local use of drugs that affect the evaluation of efficacy; Or allergies or suspected allergies to study drugs; 3) Patients with severe rhinitis and nasal malformations; 4) Patients with a history of eye surgery or laser surgery within the last 3 months; 5) Patients with acute eye disease (conjunctivitis, keratitis, uveitis) or chronic eye disease; 6) Contact lens wearers; 7) Pregnant or lactating women; 8) Participated in clinical studies of other drugs or medical devices in the past 3 months;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IOP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bp, HR and SpO2;Ramsay sedation score;Retinal microcirculation related indicators; | — |
Countries
China
Contacts
Public ContactJiaqiang Zhang
Henan Provincial People's Hospita,medical
Outcome results
None listed