Severe surgical non-traumatic hemorrhage with hypofibrinogenemia
Conditions
Interventions
Intervention group:Supplementing fibrinogen
Control group:Conventional treatment
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Age >=18 years old; (2) The informed consent has been signed; (3) Hemorrhage and fibrinogen level < 2g/L.
Exclusion criteria
Exclusion criteria: 1. Hemorrhage caused by various trauma; 2. history of thromboembolic disease within 3 months; 3. known presence of acute / chronic infection; 4. any known congenital or acquired coagulation disorders (severe liver disease, disseminated intravascular coagulation (DIC), postpartum hemorrhage, traumatic hemorrhage); 5. use of coagulant active drugs before the start of treatment; 6. pregnant or lactating women; 7. the INR (international standardized ratio) of patients who took clopidogrel 5 days before operation, glycoprotein IIb/IIIa receptor antagonists or coumarins 2 days before operation exceeded 1.4; 8. Undergoing emergency surgery or infection surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemostatic time;ICU length of hospital stay;The number and type of blood products used from randomization to the completion of hemostasis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fibrinogen concentration;Changes of blood coagulation function;Hemodynamic indicators;Adverse events; | — |
Countries
China
Contacts
Public ContactZhigang Chang
Beijing Hospital
Outcome results
None listed