persistent postural-perceptual dizziness
Conditions
Interventions
PPPD group:None
Control group:None
Sponsors
Shaanxi Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed persistent postural perceptual dizziness (according to the 2017 diagnostic criteria of the Bárány Society): A. Presence of one or more of the symptoms of dizziness, unsteadiness, non-rotational vertigo most of the time for a duration = 3 months. 1. Symptoms last for a long time, often for several hours, but the severity of symptoms can fluctuate. 2. Symptoms do not need to last for 24 hours in 1 day. B. There is no clear cause for persistent vestibular symptoms, but the following 3 factors can cause symptoms to worsen. 1. Stand upright. 2. Active or passive movement, but regardless of the direction or position of movement. 3. Exposure to mobile visual stimuli or complex visual environments. C. Usually triggered by disorders that cause dizziness/vertigo, balance disorders, including acute/episodic/chronic vestibular syndromes, other neurological, medical, and psychiatric disorders. 1. When the triggering event is acute/episodic disease, after the triggering event is relieved, the patient's clinical symptoms show the pattern shown in diagnostic criteria A. Symptoms may initially be intermittent and then persistent. 2. When the triggering event is a chronic syndrome, the patient's clinical symptoms are characterized by slow onset and gradual aggravation. D. Symptoms cause significant distress or dysfunction to the patient. E. Symptoms cannot be better explained by other diseases.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria will be excluded from the study: A. Individuals with severe cardiac conditions, such as those with a history of intracardiac mural thrombosis, atrial fibrillation, myocardial infarction, among others; B. Individuals with significant hepatic and renal insufficiency; C. Individuals with severe neurological disorders, including cerebral hemorrhage, extensive cerebral infarction, subarachnoid hemorrhage, and severe encephalitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum oxytocin level;Single nucleotide polymorphism genotyping of the oxytocin receptor gene;Dizziness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Voices acceptance and action;balance;Depression;Anxiety; | — |
Countries
China
Contacts
Public Contactzhang Xin
Shaanxi Provincial People's Hospital
Outcome results
None listed