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Effect of Afentanil hydrochloride combined with remazolam besylate on the incidence of intraoperative hypotension in elderly patients

Effect of Afentanil hydrochloride combined with remazolam besylate on the incidence of intraoperative hypotension in elderly patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094133
Enrollment
Unknown
Registered
2024-12-17
Start date
2025-01-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative hypotension in elderly patients undergoing surgery

Interventions

Experimental group:Alfentanil combined with remazolam was used for induction and maintenance of anesthesia
Control group:Remifentanil combined with propofol was used for induction and maintenance of anesthesia

Sponsors

People's Hospital of Leshan
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >=60 years old; 2.Patients undergoing elective thoracic and abdominal surgery; 3.ASA grades I-III; 4.Voluntarily sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients with hypertension or hypotension before surgery; 2.Allergic or contraindicated to benzodiazepines, opioids, propofol, muscle pine and other drugs and their drug components; 3.Intellectual or mental impairment, inability to cooperate with the patient; 4.Participated in drug clinical trials as a subject within the past 3 months; 5.Patients refusing to sign consent forms.

Design outcomes

Secondary

MeasureTime frame
The changes of blood pressure and heart rate during intubation and incision were compared between the two groups;The incidence of postoperative complications was compared between the two groups;

Primary

MeasureTime frame
The incidence of intraoperative hypotension was compared between the two groups;

Countries

China

Contacts

Public ContactLin Hongyan

People's Hospital of Leshan

xiaosa0801@163.com+86 833 2119487

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026