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Correlation between 5-HTR gene polymorphisms and clinical phenotype of facial pain

Correlation between 5-HTR gene polymorphisms and clinical phenotype of facial pain

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094132
Enrollment
Unknown
Registered
2024-12-17
Start date
2024-12-31
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic masticatory myalgia

Interventions

Simple-type CMM sham TENS group:sham transcutaneous electrical nerve stimulation
Simple-type CMM TENS group :transcutaneous electrical nerve stimulation
referred pain-type CMM TENS group:transcutaneous electrical nerve stimulation
referred pain-type CMM sham TENS group:sham transcutaneous electrical nerve stimulation

Sponsors

Affiliated Hospital of Stomatology, Nanjing Medical University,
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1).Individuals aged 18 years or older, of Han ethnicity; (2).Diagnosed with CMM (Craniomandibular Disorder) using the DC/TMD Scale (Diagnostic Criteria for Temporomandibular Disorders), with pain lasting for more than 3 months; (3) For referred pain-type CMM, diagnosis is made based on the ICHD-3 diagnostic criteria (International Classification of Headache Disorders, 3rd edition).

Exclusion criteria

Exclusion criteria: (1).Presence of systemic diseases (including rheumatic diseases, heart diseases, psychological disorders, neurological disorders, etc.); (2).History of skeletal muscle injuries or facial injuries; (3).History of long-term medication use, as well as medication use within 24 hours prior to participation in the experiment.

Design outcomes

Primary

MeasureTime frame
Masticatory muscle electromyography;Pressure pain threshold (PPT);Mandibular movements;Velocity of mandibular movement;

Countries

China

Contacts

Public ContactYuanxiu Zhang

Affiliated Hospital of Stomatology, Nanjing Medical University

75677671@qq.com+86 137 7066 5478

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026