lung tumor
Conditions
Interventions
remimazolam group:Intravenous injection of 0.25 mg/kg remimazolam.
Propofol group:Intravenous injection of 2mg/kg medium long chain propofol.
Sponsors
Chongqing University Three Gorges Hospital (Chongqing Three Gorges Central Hospital)
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 60-80 years old, gender is not limited; 2. Thoracoscopic surgery was performed under general anesthesia with double lumen endobronchial tube; 3. Preoperative American Society of Anesthesiologists (Asa) grade: I ~ III; 4. There was no cognitive behavior disorder before operation; 5. The function of heart and lung was basically normal; 6. No serious heart and brain diseases were found.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to any of the drugs used in the study; 2. Preoperative complications included schizophrenia, severe depression, neurological or psychiatric disorders; 3. Preoperative dependence on sedative drugs or addiction to narcotic analgesics and alcohol; 4. History of cerebrovascular accident, serious cardiovascular system, respiratory system, liver and kidney diseases; 5. The score on the Simplified Mental State Scale after admission is less than 24 points, and the patient is unable to understand the written information or informed consent form of the trial; 6.A ny disease affecting the placement of double lumen tubes with bronchial lesions and stenosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum inflammation, stress, cognitive function related factors;Venous blood routine (white blood cell, neutrophil, lymphocyte count, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS value;Noninvasive cerebral oxygen saturation and blood oxygen saturation;Hemodynamics: blood pressure, mean arterial pressure, heart rate;Injection pain, hypotension, bradycardia, respiratory depression, postoperative nausea/vomiting (PONV), pulmonary infection, incision infection;Anesthesia induced eyelash reflex disappearance time, BIS value reduced to 60 time, anesthesia recovery time, recovery room residence time;The concentrations of serum cortisol, norepinephrine, malondialdehyde and ß - endorphin in venous blood.;Incidence of delirium and cognitive dysfunction (POCD) within 7 days after operation; | — |
Countries
China
Contacts
Public ContactLiu Chun
Chongqing University Three Gorges Hospital (Chongqing Three Gorges Central Hospital)
Outcome results
None listed