Acute postoperative pain
Conditions
Interventions
Group Oliceridine:Oliceridine
Group Fentanil:Fentanil
Sponsors
Chongqing Emergency Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Undergoiong unilateral lower extremity fracture operation; 2.Age between 18 years old and 65 years old; 3.ASA Grade I - III; 4.BMI=18-35kg/m2; 5.Operation time between 1 hour and 3 hours;
Exclusion criteria
Exclusion criteria: 1.Opioid allergy and recent use of opioids; 2.Patients with opioid contraindications; 3.Pregnant and lactating women; 4.Abnormal mental or neurological function; 5.Patients with major organ dysfunction: NYHA cardiac function grade =?; Pulmonary function grade of COPD patients =?; The Child-Pugh grade of liver function reached B and C grades. eGFR<60ml/min; 6.Patients with pain in other areas; 7.Patients reject to participate in this study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 48-hour postoperative NRS; | — |
Countries
China
Contacts
Public ContactHong Fu
Chongqing Emergency Medical Center
Outcome results
None listed